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CONTEXT : During the ageing process, the cerebrovascular system undergoes a subclinical change which plays an important role in the deterioration of brain functions. We believe that it is realistic to envisage attenuating this evolution, with an aim to improving the well-being of the elderly population and of preserving their cognitive functions (memory, comprehension, faculty to communicate, etc?) for as long as possible.

METHODS : We are planning to undertake a multi-disciplinary study to assess the cerebrovascular system in the accelerated-ageing mouse (SAM-P8). The preliminary experiments that we have carried out, have confirmed the interest of this model. The following techniques will be implemented. In vivo, magnetic resonance imaging (MRS), confocal scanning laser ophthalmoscopy » (cSLO). In vitro, assessment of the inflammatory condition through the analysis of multiplex cytokins and a proteomic («omic») study. Cerebral metabolic energy will be examined by in vivo magnetic resonance spectroscopy  (MRS). Behaviour tests will be carried out.

OBJECTIVE : Our objective is to show that it could be possible to achieve considerable protection of brain blood circulation using a combination of polyunsaturated fatty acids (n-3 PUFA) and pantethin (pro-vitamin B5). These two families of constituents have synergic effects which have shown their effectiveness at the cardio- and cerebrovascular level.

EXPECTED RESULTS : We want to show that these constituents, introduced via a «naturel» orifice, that is to say via food supplements, may be able to attenuate the changes in blood circulation throughout ageing and preserve the cognitive functions.

Partners :


This project, labellised by the AQUIMER Pole of Competitiveness on the 10th March, 2011, is co-labellised by Pôle Vitagora.


16 rue du Commandant Charcot
62200 Boulogne-sur-Mer F

Tel : 00 333 21 10 78 98

Fax : +33 3 21 30 33 22



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