PATHOTRACKFISH

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For around twenty years, the supplies of world fishing have been stable and no significant increase is forecast due to the present state of wild fish stocks. Future supply of aquatic products for the world market therefore relies on the rapid expansion of aquaculture. According to the FAO, in order to meet needs, aquacultural production must increase two-fold by 2030. Although world aquaculture has developed considerably (it is the agri-food sector that has experienced the fastest growth) it has to meet many challenges.
Sanitary conditions are a major constraint in the development of aquaculture and limit the production of aquaculture farms.

The aims of the project are to develop and use tools which are derived directly from knowledge of bacterial genomes in order to gain a better understanding of the emergence of pathogens of the Tenacibaculum type and to take rational prophylactic steps in fish farming. This means:
1- building a collection of reference strains of Tenacibaculum fish pathogens and genetically characterising these strains with a reference method (Multi-Locus Sequence Typing) in order to elucidate the structure of the populations of bacteria that attack farms,
2-studying the genome of some of these strains using the most advanced sequencing and optical cartography methods in order to identify the genetic determinants associated with virulence and the adaptation of Tenacibaculum pathogens to their hosts as well as the targets for the development of a method of terrain typing
3- developing and validating detection and epidemiological monitoring tools for the strains which can be used by players in the industry,
4- carrying out a rational assessment of a candidate vaccine.

This project, labelised by the AQUIMER pole of Competitiveness on the 22nd April, 2010, is co-labelised by the 'Pôles Atlanpôle Biothérapies' and 'Qu@limed'.

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62200 Boulogne-sur-Mer F

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